1.7. Analysis.

Comparison 1 Oropharyngeal colostrum (OPC) versus control (water, saline, or no intervention), Outcome 7 Reported adverse effects.

Reported adverse effects
Study	Outcome	Definition	Comments
Glass 2017	No adverse effects reported.	Infants were monitored for apnea, bradycardia and aspiration pneumonia.	"There were no apenic, bradycardic events reported with oropharyngeal colostrum or sterile water administration."
McFadden 2012	No adverse effects have been reported	No pre‐defined adverse effects have been described in the study	Adverse effects were narratively reported as no adverse effects with the intervention. No numerical data were provided
NCT02912585	No adverse effects have been reported	No pre‐defined adverse effects have been described in the study	"The subjects tolerated the intervention and there were no adverse effects during the protocol treatment. No numerical data provided."
Rodriguez 2011	No adverse effects have been reported	No pre‐defined adverse effects have been described in the study	"All subjects tolerated the intervention and there were no recorded episodes of apnea, bradycardia, hypotension, desaturation or other adverse effects during the treatment protocol". No numerical data were provided
Romano‐Keeler 2016	No adverse effects have been reported	No pre‐defined adverse effects have been described in the study	"No adverse events were noted among patients in either group during the course of the study". No numerical data were provided
Sohn 2015	No adverse effects have been reported	No pre‐defined adverse effects have been described in the study	No data or comment in the report.