Comparison 2. Protease activity dichotomous.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Association of healing with elevated protease level; by protease modulating (PM) intervention	3		Risk Ratio (Fixed, 95% CI)	Totals not selected
1.1 Elastase > 25 mU/100 μL vs ≤ 25 mU/100 μL + PM intervention	1		Risk Ratio (Fixed, 95% CI)	0.0 [0.0, 0.0]
1.2 MMP (unspecified) level ≥ 5 (0‐10 scale) vs < 5 + possible PM intervention	1		Risk Ratio (Fixed, 95% CI)	0.0 [0.0, 0.0]
1.3 MMP (unspecified) level ≥ 5 (0‐10 scale) vs < 5 + non‐PM intervention	1		Risk Ratio (Fixed, 95% CI)	0.0 [0.0, 0.0]