Date	Event	Description
22 March 2018	New citation required and conclusions have changed	New citations, conclusions changed. For this update, we identified 6 new published studies. One study compared IV ibuprofen to placebo (Ding 2014); one study compared IV ibuprofen to IV indomethacin (Lin 2017); one study compared high versus standard dose of ibuprofen (Pourarian 2015); one study compared rectal versus oral ibuprofen (Demir 2017); one study compared IV ibuprofen to oral ibuprofen (Akar 2017) and one study compared IV ibuprofen to IV indomethacin( El‐Mashad 2017)
11 February 2018	New search has been performed	Thirty‐nine studies reporting on 2843 infants are included in this review. Currently there are at least 11 ongoing studies relevant to this review.