Plavka 2001

Methods	Three centre, randomised controlled trial in 3 NICUs in the Czech Republic. Study period: not stated
Participants	41 preterm infants with clinical and ECHO signs of PDA were randomised Ibuprofen: 21 infants, mean (SD) GA 27.6 (2.3) weeks; BW 929 (213) grams Indomethacin: 20 infants, mean (SD) GA 26.9 (1.7) weeks; BW 902 (211) grams
Interventions	Ibuprofen: IV 8 mg/kg every 24 hours for 3 doses Indomethacin: IV 0.2 mg/kg every 24 hours for 3 doses If PDA persisted, treatment was repeated at half dose every 24 hours for 6 doses. Persistent PDA was ligated
Outcomes	Cerebral blood flow velocities, blood pressure, serum creatinine, mortality, and ductal reopening
Notes	Published in abstract form only. No information on funding provided
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No information provided
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information provided
Incomplete outcome data (attrition bias) All outcomes	Low risk	Complete follow‐up ‐ yes
Selective reporting (reporting bias)	Unclear risk	Study protocol was not available to us so we could not ascertain if there were deviations from the protocol
Other bias	Low risk	Appeared free of other bias