IRCT2015111024977N1

Trial name or title	Comparison of oral ibuprofen and intravenous indomethacin for the treatment of patent ductus arteriosus
Methods	Randomised controlled trial
Participants	Preterm infants: PMA between 29 weeks and six days to 35 weeks and six days, between 1000 and 2500 grams birth weight, postnatal age 72 to 120 hours
Interventions	In the intervention group: treatment with ibuprofen dose: 10 mg per kg and then to 5 mg per kg at 24 and 48 hours after birth. In the comparison group: treatment with Indomethacin dose: 0.2 milligrams per kilogram at 24 and 48 hours after birth
Outcomes	Primary outcomes: thrombocytopenia, pulmonary haemorrhage, increased creatinine, increased bilirubin Secondary outcomes: closure of PDA
Starting date	August 2014
Contact information	Seyedeh Masoomeh Mohaqeqi Kamal, Qom University of Medical Sciences, Iran. Phone +98 25 3663 3608. Email address ho.mohaghegh@uswr.ac.ir
Notes	Registered while recruiting. Recruitment completed