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. 2018 Jul 9;2018(7):CD011151. doi: 10.1002/14651858.CD011151.pub3

Comparison 1. Low versus high tidal volume.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Mortality within 30 days 12 1207 Risk Ratio (M‐H, Fixed, 95% CI) 0.80 [0.42, 1.53]
2 Pneumonia 7 778 Risk Ratio (M‐H, Fixed, 95% CI) 0.45 [0.25, 0.82]
3 Need for postoperative non‐invasive ventilation 3 506 Risk Ratio (M‐H, Fixed, 95% CI) 0.31 [0.15, 0.64]
4 Need for postoperative invasive ventilation 11 957 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.14, 0.77]
5 Intensive care unit length of stay (days) 5 898 Std. Mean Difference (Random, 95% CI) ‐0.06 [‐0.22, 0.10]
6 Hospital length of stay divided in subgroups according to positive end‐expiratory pressure (PEEP) use (days) 14 1298 Std. Mean Difference (Random, 95% CI) ‐0.15 [‐0.29, ‐0.00]
6.1 PEEP used for both groups 8 537 Std. Mean Difference (Random, 95% CI) ‐0.08 [‐0.33, 0.18]
6.2 PEEP used for low tidal volume group only 7 761 Std. Mean Difference (Random, 95% CI) ‐0.23 [‐0.38, ‐0.08]
7 Hospital length of stay divided in subgroups according to recruitment manoeuvres or not (days) 14 1298 Std. Mean Difference (Random, 95% CI) ‐0.15 [‐0.29, ‐0.00]
7.1 Recruitment manoeuvres in low tidal volume group only 4 638 Std. Mean Difference (Random, 95% CI) ‐0.25 [‐0.41, ‐0.09]
7.2 Recruitment manoeuvres in high tidal volume group only 1 40 Std. Mean Difference (Random, 95% CI) 0.0 [‐0.62, 0.62]
7.3 Recruitment manoeuvres in both groups 3 254 Std. Mean Difference (Random, 95% CI) 0.16 [‐0.09, 0.40]
7.4 No recruitment manoeuvres mentioned 6 366 Std. Mean Difference (Random, 95% CI) ‐0.26 [‐0.50, ‐0.02]
8 Pneumothorax 5 708 Risk Ratio (M‐H, Fixed, 95% CI) 1.77 [0.52, 5.99]