Skip to main content
. 2018 Jul 9;2018(7):CD011151. doi: 10.1002/14651858.CD011151.pub3

Xiong 2016.

Methods RCT with parallel groups
Approved by the ethics committee
Informed consents obtained
Site: First Affiliated Hospital of Chongqing Medical University, China
Setting: university hospital
Dates of data collection: unspecified
Participants 60 ASA I or II participants aged ≥ 40 years undergoing elective spine surgery in the prone position for ≥ 3 hours and with a risk of complications score ≥ 26
Exclusion criteria: receiving mechanical ventilation 2 weeks before surgery; BMI ≥ 35 kg/m2; acute infection or sepsis 2 weeks before surgery; history of chronic obstructive pulmonary disease, thoracic or emergency surgery, progressive neuromuscular disease, acute lung injury or ARDS; need prolonged mechanical ventilation after surgery; poorly controlled hypertension; drug allergy; nausea and vomiting; history of psychological or neurological disease; or receiving chemotherapy or radiotherapy
Interventions Treatment group: tidal volume 6 mL/kg, PEEP 5 cmH2O and recruitment manoeuvres every 30 min (n = 30)
Control group: tidal volume 10 mL/kg (n = 30)
Outcomes Relevant to this review

  1. Pneumonia (clinical pulmonary infection score)


Others

  1. Arterial blood gas

  2. PaO2/FiO2 ratio

  3. Peak and plateau airway pressures

  4. Haemodynamic variables

  5. White blood cells and percentage of neutrophils

  6. C‐reactive protein

  7. Pulmonary complication risk score

  8. Duration of mechanical ventilation

  9. Pain scores
Notes Funding: Ministry of Health, the National Key Laboratory of Clinical Specialties (Finance and Social Sciences (2011) No. 170); Chongqing Municipal Medical Key Discipline Project (Chongqing Wei Science and Education (2007) 2); Chongqing Municipal Health Bureau of Medical Science Key Project (2012‐018) Health Bureau Medical Research Project (2012‐1‐018)
Declaration of interest: none mentioned
Email sent to authors to request the number of participants who were diagnosed as having a pneumonia after surgery 17 June 2017. No reply received
Volume per body weight: predicted body weight; men: 50 + 0.91 × (height in cm – 152.4); women: 45.5 + 0.91 × (height in cm – 152.4)
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "randomized"
Allocation concealment (selection bias) Unclear risk Not mentioned
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Not mentioned
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Not mentioned
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No loss to follow‐up
Selective reporting (reporting bias) Low risk All results reported
Other bias Low risk Groups well balanced