| 1 All‐cause mortality at 6 to 12 months |
4 |
294 |
Risk Ratio (M‐H, Random, 95% CI) |
1.42 [1.02, 1.97] |
| 2 Sensitivity analysis: all‐cause mortality |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 3 Cryptococcal meningitis relapse |
2 |
205 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.27 [0.07, 1.04] |
| 4 Mortality hazard ratio |
3 |
|
Hazard Ratio (Random, 95% CI) |
Totals not selected |
| 5 Cryptococcal IRIS |
2 |
205 |
Risk Ratio (M‐H, Random, 95% CI) |
3.56 [0.51, 25.02] |
| 6 Sensitivity analysis: cryptococcal IRIS |
2 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 6.1 Available‐case analysis: all who received ART (assume missing completely at random) |
2 |
178 |
Risk Ratio (M‐H, Random, 95% CI) |
2.97 [0.38, 23.25] |
| 6.2 As randomized: intention‐to‐treat analysis |
2 |
205 |
Risk Ratio (M‐H, Random, 95% CI) |
3.56 [0.51, 25.02] |
| 6.3 Worst‐case scenario |
2 |
205 |
Risk Ratio (M‐H, Random, 95% CI) |
3.73 [0.37, 38.07] |
| 6.4 Best‐case scenario |
2 |
205 |
Risk Ratio (M‐H, Random, 95% CI) |
1.56 [0.45, 5.40] |
| 7 Virological suppression at 24 weeks (viral load < 400 copies/mL) |
2 |
205 |
Risk Ratio (M‐H, Random, 95% CI) |
0.93 [0.72, 1.22] |
| 8 Sensitivity analysis: virological suppression at 24 weeks |
2 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 8.1 Available‐case analysis (assume missing completely at random) |
2 |
128 |
Risk Ratio (M‐H, Random, 95% CI) |
1.10 [0.96, 1.27] |
| 8.2 Intention‐to‐treat analysis (assume missing would not have suppressed) |
2 |
205 |
Risk Ratio (M‐H, Random, 95% CI) |
0.93 [0.72, 1.22] |
| 8.3 Best‐case scenario |
2 |
205 |
Risk Ratio (M‐H, Random, 95% CI) |
1.26 [1.10, 1.45] |
| 8.4 Worst‐case scenario |
2 |
205 |
Risk Ratio (M‐H, Random, 95% CI) |
0.84 [0.72, 0.96] |
| 9 Subgrouping by antifungal drug: all‐cause mortality |
4 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Totals not selected |
| 9.1 Ampho B + fluconazole |
2 |
|
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 9.2 Fluconazole |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 9.3 Unknown antifungal drug |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
