Date	Event	Description
23 July 2018	New search has been performed	This is an update of a review last published in 2013 (Njei 2013). The review author team updated the protocol extensively, and differences are highlighted in the ‘Differences between protocol and review' section.
23 July 2018	New citation required and conclusions have changed	The previous Cochrane Review conducted by Njei 2013 concluded that there was insufficient evidence to determine whether early ART had an effect on mortality and suggested that there was a higher risk of IRIS among those who initiated ART early. This review update did show some evidence of higher risk of IRIS in the early ART group, but the certainty of the evidence contributing to this outcome was very low. The additional trials that contributed to this updated review, and rigorous application of the GRADE tool, resulted in low‐certainty evidence of higher mortality among those who initiated ART early.