| 1 Admission to hospital |
12 |
960 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.44 [0.31, 0.62] |
| 1.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
5 |
433 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.54 [0.36, 0.81] |
| 1.2 ICS vs. placebo |
7 |
527 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.27 [0.14, 0.52] |
| 2 FEV1 at 1 hour |
4 |
248 |
Mean Difference (IV, Random, 95% CI) |
0.28 [‐0.22, 0.77] |
| 2.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
0.0 [‐0.34, 0.34] |
| 2.2 ICS vs. placebo |
3 |
188 |
Mean Difference (IV, Random, 95% CI) |
0.37 [‐0.32, 1.07] |
| 3 FEV1 at 2 hours |
3 |
203 |
Mean Difference (IV, Random, 95% CI) |
0.05 [‐0.23, 0.33] |
| 3.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
‐0.10 [‐0.45, 0.25] |
| 3.2 ICS vs. placebo |
2 |
143 |
Mean Difference (IV, Random, 95% CI) |
0.10 [‐0.27, 0.48] |
| 4 FEV1 at 3 to 4 hours |
4 |
319 |
Mean Difference (IV, Random, 95% CI) |
0.15 [‐0.09, 0.39] |
| 4.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
‐0.10 [‐0.46, 0.26] |
| 4.2 ICS vs. placebo |
3 |
259 |
Mean Difference (IV, Random, 95% CI) |
0.23 [‐0.01, 0.47] |
| 5 FEV1 at 5 to 6 hours |
2 |
106 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.13 [‐0.42, 0.16] |
| 5.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
57 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐0.49, 0.29] |
| 5.2 ICS vs. placebo |
1 |
49 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.16 [‐0.59, 0.27] |
| 6 FEV1 (% predicted) at 1 hour |
4 |
324 |
Mean Difference (IV, Fixed, 95% CI) |
2.13 [‐1.10, 5.36] |
| 6.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
3.30 [‐6.73, 13.33] |
| 6.2 ICS vs. placebo |
3 |
264 |
Mean Difference (IV, Fixed, 95% CI) |
1.99 [‐1.42, 5.41] |
| 7 FEV1 (% predicted) at 2 hours |
4 |
319 |
Mean Difference (IV, Fixed, 95% CI) |
3.81 [0.28, 7.33] |
| 7.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
2.0 [‐8.23, 12.23] |
| 7.2 ICS vs. placebo |
3 |
259 |
Mean Difference (IV, Fixed, 95% CI) |
4.05 [0.30, 7.80] |
| 8 FEV1 (% predicted) at 3 to 4 hours |
4 |
319 |
Mean Difference (IV, Fixed, 95% CI) |
5.93 [2.11, 9.75] |
| 8.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
3.0 [‐7.95, 13.95] |
| 8.2 ICS vs. placebo |
3 |
259 |
Mean Difference (IV, Fixed, 95% CI) |
6.34 [2.26, 10.42] |
| 9 FEV1 (% predicted) at 5 to 6 hours |
2 |
106 |
Mean Difference (IV, Fixed, 95% CI) |
1.43 [‐5.67, 8.53] |
| 9.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
57 |
Mean Difference (IV, Fixed, 95% CI) |
1.0 [‐10.49, 12.49] |
| 9.2 ICS vs. placebo |
1 |
49 |
Mean Difference (IV, Fixed, 95% CI) |
1.70 [‐7.33, 10.73] |
| 10 PEF at 1 hour |
5 |
289 |
Mean Difference (IV, Fixed, 95% CI) |
10.22 [‐6.13, 26.57] |
| 10.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
‐23.5 [‐95.66, 48.66] |
| 10.2 ICS vs. placebo |
4 |
200 |
Mean Difference (IV, Fixed, 95% CI) |
14.50 [‐4.15, 33.15] |
| 10.3 ICS vs. placebo without spacer |
1 |
29 |
Mean Difference (IV, Fixed, 95% CI) |
1.57 [‐36.95, 40.09] |
| 11 PEF at 2 hours |
3 |
208 |
Mean Difference (IV, Random, 95% CI) |
14.32 [‐33.54, 62.18] |
| 11.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
‐22.90 [‐94.11, 48.31] |
| 11.2 ICS vs. placebo |
2 |
148 |
Mean Difference (IV, Random, 95% CI) |
27.21 [‐26.83, 81.26] |
| 12 PEF at 5 to 6 hours |
3 |
135 |
Mean Difference (IV, Random, 95% CI) |
0.83 [‐62.87, 64.53] |
| 12.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
57 |
Mean Difference (IV, Random, 95% CI) |
‐30.70 [‐106.40, 45.00] |
| 12.2 ICS vs. placebo |
2 |
78 |
Mean Difference (IV, Random, 95% CI) |
12.19 [‐72.49, 96.87] |
| 13 PEF at 3 to 4 hours |
5 |
348 |
Mean Difference (IV, Random, 95% CI) |
26.07 [‐1.17, 53.31] |
| 13.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
‐39.80 [‐108.45, 28.85] |
| 13.2 ICS vs. placebo |
4 |
288 |
Mean Difference (IV, Random, 95% CI) |
37.44 [16.92, 57.96] |
| 14 PEF (% predicted) at 1 hour |
4 |
324 |
Mean Difference (IV, Fixed, 95% CI) |
5.66 [2.01, 9.32] |
| 14.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.13 [‐17.08, 12.82] |
| 14.2 ICS vs. placebo |
3 |
264 |
Mean Difference (IV, Fixed, 95% CI) |
6.16 [2.39, 9.93] |
| 15 PEF (% predicted) at 2 hours |
5 |
384 |
Mean Difference (IV, Fixed, 95% CI) |
7.46 [3.77, 11.15] |
| 15.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.80 [‐16.56, 12.96] |
| 15.2 ICS vs. placebo |
4 |
324 |
Mean Difference (IV, Fixed, 95% CI) |
8.07 [4.27, 11.88] |
| 16 PEF (% predicted) at 3 to 4 hours |
4 |
324 |
Mean Difference (IV, Fixed, 95% CI) |
7.19 [3.05, 11.33] |
| 16.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.27 [‐19.80, 9.26] |
| 16.2 ICS vs. placebo |
3 |
264 |
Mean Difference (IV, Fixed, 95% CI) |
8.29 [3.97, 12.61] |
| 17 PEF (% predicted) at 5 to 6 hours |
2 |
114 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.87 [‐10.59, 8.84] |
| 17.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.20 [‐18.49, 12.09] |
| 17.2 ICS vs. placebo |
1 |
54 |
Mean Difference (IV, Fixed, 95% CI) |
0.70 [‐11.88, 13.28] |
| 18 Clinical score at 1 to 2 hours |
4 |
176 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.29 [‐0.59, 0.01] |
| 18.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
26 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.38 [‐1.16, 0.40] |
| 18.2 ICS vs. placebo |
3 |
150 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.25 [‐0.66, 0.16] |
| 19 Clinical score at 3 to 4 hours |
4 |
194 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.33 [‐0.62, ‐0.05] |
| 19.1 ICS + systemic corticosteroids vs. systemic corticosteroids |
1 |
44 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.15 [‐0.74, 0.45] |
| 19.2 ICS vs. placebo |
3 |
150 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.37 [‐0.73, ‐0.02] |
| 20 Vital signs |
7 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 20.1 Respiratory rate |
3 |
198 |
Mean Difference (IV, Random, 95% CI) |
0.57 [‐1.69, 2.83] |
| 20.2 Heart rate |
5 |
363 |
Mean Difference (IV, Random, 95% CI) |
3.99 [0.59, 7.39] |
| 20.3 Oxygen saturation |
5 |
301 |
Mean Difference (IV, Random, 95% CI) |
‐0.18 [‐0.66, 0.31] |
| 20.4 Systolic blood pressure |
3 |
128 |
Mean Difference (IV, Random, 95% CI) |
‐0.32 [‐4.00, 5.36] |
| 21 Adverse effects |
3 |
|
Odds Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 21.1 Nausea/vomiting |
1 |
94 |
Odds Ratio (M‐H, Random, 95% CI) |
0.32 [0.03, 3.18] |
| 21.2 *Tremor |
3 |
309 |
Odds Ratio (M‐H, Random, 95% CI) |
1.44 [0.84, 2.45] |
| 22 Admission to hospital subgrouped children vs. adults |
12 |
960 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.44 [0.31, 0.62] |
| 22.1 Adults |
5 |
377 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.35 [0.20, 0.60] |
| 22.2 Children |
7 |
583 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.52 [0.33, 0.80] |
| 23 Admission to hospital subgrouped high vs. low dose |
12 |
960 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.44 [0.31, 0.62] |
| 23.1 High dose |
8 |
775 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.51 [0.35, 0.74] |
| 23.2 Low dose |
4 |
185 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.20 [0.08, 0.49] |
| 24 Admission to hospital subgrouped by delivery devices |
11 |
906 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.45 [0.32, 0.63] |
| 24.1 Nebuliser |
7 |
572 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.53 [0.35, 0.82] |
| 24.2 MDI and spacer |
4 |
334 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.32 [0.18, 0.59] |
