A. DETAILS
Describe methods of patient selection (cut and paste from paper if possible)
Describe characteristics included patients; previous testing, presentation, intended use of index test, and setting (cut and paste from paper if possible)
Number of participants
Setting	o Medical ICU o Surgical ICU o Mixed ICU o Other ICUs
Eligibility criteria
Exclusion criteria
Age
Gender
Co‐morbidities
Type of ventilatory assistance	o Mechanical o Spontaneous
B. ASSESSMENT RISK OF BIAS
Was a consecutive or random sample of patients enrolled?	o “Yes” if it is well described in the paper that a consecutive or random sample of consecutive patients admitted to the intensive care unit were enrolled. o “No” if the sample was non‐random or ICU patients were not consecutively recruited. o “Unclear” if there is insufficient information to make a judgment on the selection of patients.
Was a case control design avoided?	o “Yes” = The study used other research design (such as cross‐sectional and cohort). o “No” = The study should be excluded for this review (see eligibility criteria). o Unclear= if there is insufficient information to make a judgment on the design.
Did the study avoid inappropriate inclusions?	o “Yes” if inclusion and exclusion criteria clearly described and appropriate. o “No” if inclusion and exclusion criteria clear but include inappropriate subjects, such as patients admitted in non‐critical units, pediatric population or patients with history of severe dementia, psychosis, or neurologic disease that would confound the diagnosis of delirium. o Unclear” if there is insufficient information to make a judgment on the inclusion/exclusion of subjects.
Could the selection of patients have introduced bias?	o “High” if it is clear that bias is introduced through, for example, non‐random selection. o “Low” if the selection of patients is clearly described and does not introduce bias. o “Unclear” if there is insufficient information to make a judgment on the impact of selection on bias.
C. CONCERNS ABOUT APLICABILITY
Are there concerns that included patients do not match the review question?	o “High” if included patients are inherently different from the cohort of patients who would be expected to receive the CAM‐ICU. o “Low” if there are no such concerns. o “Unclear” if patient characteristics are not sufficiently clearly explained to make a judgment on patient inclusion.