A. DETAILS
Describe the index test and how it was conducted and interpreted (cut and paste from paper if possible)
Frequency of testing
Operator characteristics (e.g. training)
Thresholds/Criteria used to define positive and negative tests for target condition
B. ASSESSMENT RISK OF BIAS
Were the index test results interpreted without knowledge of the results of the reference standard?	o “Yes” if the paper states that the CAM‐ICU is interpreted by clinician/ researcher who did not know the results of the reference standard. o “No” if the results of the index test were known by the clinicians performing the reference test, or if the same clinician/researcher performed both tests. o “Unclear” if there is insufficient information to make a judgment about test result interpretation.
If a threshold was used, was it prespecified?	o “Yes” if the research used a pre‐specified criteria of positivity (Feature 1 plus 2 and either 3 or 4 present = CAM‐ICU positive= delirium present). o “Unclear” if there is no clear the CAM‐ICU positive criteria used. o “No” if there are explorations of positivity criteria in the data analysis.
Could the conduct or interpretation of the index test have introduced bias?	o “High” if a subset of CAM‐ICU tests were conducted or interpreted in a different manner, or under different conditions, or by people with differing levels of training. o “Low” if it is clear that the conduct and interpretation of CAM‐ICU was appropriate and could not have introduced bias. o “Unclear” if there is insufficient information presented to assess the potential of conduct and interpretation of the CAM‐ICU to introduce bias.
C. CONCERNS ABOUT APLICABILITY
Are there concerns that the index test, its conduct, or interpretation differ from the review question?	o “Yes” if the index test is not the CAM‐ICU for diagnosis of delirium, or if the conduct of test or its interpretation is not applicable to the review question. o “No” if there are no concerns based on the information presented. o “Unclear” if the conduct of test or its interpretation are not sufficiently clearly explained to make a judgment on this issue.