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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: FEBS Lett. 2019 Apr 4;593(9):971–981. doi: 10.1002/1873-3468.13364

Figure 1. Thg1 specifies tRNAHis identity through a non-Watson Crick 3’-5’ addition of G−1 across from A73.

Figure 1.

Pre-tRNA 5’-leader sequences are removed by the 5’-endoribonuclease activity of Ribonuclease P (RNase P), generating the 5’-monophosphorylated tRNAHis that is the substrate for Thg1 to add G−1.