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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Basic Clin Pharmacol Toxicol. 2019 Jan 10;124(6):670–680. doi: 10.1111/bcpt.13194

Figure 4. STV preserves normal metalloproteinase (MMP) levels and activity.

Figure 4.

MMP-9 and MMP-2 activities were analysed by zymography using gelatin-substrate gels in liver sections of control, TAA, STV+TAA, and STV only rats. Histograms depict signal intensities that were determined by densitometric analysis for MMP-9 and MMP-2 (A). Representative immunohistochemistry for MMP-13 obtained from control rats (B); TAA-treated rats (C); STV+TAA-treated rats (D) and rats administered with STV alone (E). Histograms depict the percentage of positivity of MMP-13 obtained from immunohistochemistry slices and protein expression levels of pro-MMP-13 and active MMP-13 by western blot from liver slices (F). β-actin was used as a control. The values are expressed as a fold increase of optical densitometry normalized to the control group values (control = 1). Each bar represents the mean value of experiments conducted in duplicate assays ± SEM (n = 3). ap < 0.05 vs control. bp < 0.05 vs TAA.