Table 2.
Change in pre- and post-treatment methylation levels in tumor (t) and blood (b)
| Marker | Mean pre-treatment methylation level (sd) | Mean post-treatment methylation level (sd) | Mean change (pre-post) (sd) | p value change in methylation |
|---|---|---|---|---|
| p16 (t) | 16.71 (23.55) | 13.35 (19.03) | 3.36 (24.81) | 0.40 |
| p16 (b) | 1.14 (1.74) | 0.94 (0.64) | 0.33 (2.02) | 0.41 |
| DCC (t) | 32.63 (20.11) | 30.91 (24.98) | 1.07 (23.30) | 0.78 |
| DCC (b) | 7.43 (2.26) | 7.66 (2.42) | −0.05 (1.83) | 0.89 |
| CCNA1 (t) | 30.53 (17.90) | 32.32 (18.82) | −2.14 (22.95) | 0.61 |
| CCNA1 (b) | 15.95 (4.55) | 16.33 (3.21) | −0.17 (2.82) | 0.77 |
| NDN (t) | 43.36 (16.32) | 43.60 (12.99) | −0.24 (21.0) | 0.94 |
| NDN (b) | 36.94 (4.90) | 37.59 (5.26) | 0.15 (2.46) | 0.76 |
| GADD45 (t) | 1.76 (1.33) | 1.53 (0.67) | 0.24 (1.56) | 0.35 |
| GADD45 (b) | 0.76 (0.53) | 1.06 (0.51) | −0.33 (0.93) | 0.08 |
| LINE-1 (t) | 62.88 (12.48) | 67.78 (9.75) | −4.90 (10.15) | 0.005 |
| LINE-1 (b) | 72.43 (1.16) | 72.62 (1.17) | −0.18 (1.60) | 0.57 |
| CD1A (t) | 65.85 (12.99) | 66.41 (13.91) | −0.56 (14.98) | 0.82 |
| CD1A (b) | 87.56 (3.87) | 88.23 (3.38) | −0.75 (2.80) | 0.18 |