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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Autoimmun. 2019 Mar 8;100:52–61. doi: 10.1016/j.jaut.2019.02.006

Fig. 7. AS101 promotes Treg differentiation independently of TGF-β.

Fig. 7.

LN cells from R161H-Foxp3-GFP mice were stimulated for 96 h with 2 μg/ml IRBP161-180 in presence of TGFβ1 (5 ng/ml), or in presence of anti-TGFβ (1D11, 10 μg/ml) and graded doses of AS101 in serum-containing (A) or serum-free (B) medium. After polarization, the CD3+CD4+ population was assessed for Foxp3-GFP and CD25 expression by flow cytometry. Results represent one of 2 independent experiments. Significance was determined using ANOVA test. *p<0.05, **p<0.01 vs. PBS group.