Skip to main content
. Author manuscript; available in PMC: 2020 May 11.
Published in final edited form as: J Cell Biochem. 2018 Nov 11;120(5):7309–7322. doi: 10.1002/jcb.28005

Figure 4. Meta-analysis of PRO-seq data of Kasumi-1 cells treated with JQ1 for 1 or 3 hr.

Figure 4.

(A) MYC levels drop rapidly upon BETi treatment. Western blot analysis of Kasumi-1 (left panel) and MV4–11 (right panel) cells treated with 250 or 500 nM JQ1 for the indicated times. (B) KEGG pathway analysis of PRO-seq data31 showing genes in which promoter-proximal pausing was increased after 1 hr (left) and 3 hr (right) treatments. (C) Gene set enrichment analysis of PRO-seq data31 showed decreased expression of MYC target genes including those genes regulating ribosomal biogenesis.