Table 4.

Predictive performance of drug clearance in newborns and infants using GA-based and PNA-based maturation model

	≥ 42 weeks PMA			37 to < 42 weeks PMA			< 37 weeks PMA
Drug	AFE	AAFE	PER (%)	AFE	AAFE	PER (%)	AFE	AAFE	PER (%)
Gentamicin	1.2	1.3	95.9	1.3	1.3	97.8	1.7	1.7	91.7
Netilmicin	0.9	1.2	100.0	1.6	1.6	100.0	0.7	1.5	75
Meropenem	1.4	1.4	92.5	1.2	1.4	76.9	1.2	1.3	96.8
Ampicillin	2.5	2.5	13.5	2.3	2.3	20	2.8	2.8	16.1

AAFE, absolute average fold error; AFE, average fold error; GA, gestational age; PER, percentage of infants with a fold error between 0.5 and 2, indicating a twofold difference from the observed clearance; PNA, postnatal age.