Table IV.

Selected hematology and clinical chemistry parameters of NSG mice after three intravenous injections of 2 × 10⁶ ABCB5⁺ MSCs/animal or vehicle without cells on day 1, 15 and 29.

	Vehicle	2 × 106 MSCs/animal
Males	n = 10	n = 9
Hematology
Hematocrit, L/L	0.459 (0.0257)	0.476 (0.0144)
Hemoglobin, g/dL	12.6 (0.63)	13.0 (0.27)
White blood cells,9× 109/L	0.81 (0.207)	1.10 (0.574)
Neutrophils, × 10 /L	0.53 (0.153)	0.65 (0.233)
Lymphocytes, × 109/L	0.22 (0.126)	0.33 (0.357)
Monocytes, × 10 9/L	0.04 (0.023)	0.09 (0.039)**
Eosinophils, × 10 /L	0.02 (0.010)	0.03 (0.011)
Clinical chemistry
AST, U/L	45 (9.7)	43 (7.9)
ALP, U/L	46 (3.1)	45 (2.8)
Urea, mmol/L	8.56 (0.741)	7.72 (0.433)*
Cholesterol, mmol/L	2.63 (0.127)	2.38 (0.240)*
Triglycerides, mmol/L	1.02 (0.273)	0.61 (0.194)**
Glucose, mmol/L	14.09 (1.271)	15.82 (2.533)
Na+, mmol/L	152 (1.2)	152 (2.2)
K+, mmol/L	4.3 (0.41)	4.4 (0.32)
Ca2+, mmol/L	2.39 (0.045)	2.34 (0.072)*
Albumin, g/L	31 (1.1)	29 (0.8)**
Total protein, g/L	49 (1.3)	46 (1.5)**
Females	n = 10	n = 10
Hematology
Hematocrit, l/L	0.490 (0.0096)	0.478 (0.0154)*
Hemoglobin, g/dL	13.6 (0.38)	13.5 (0.43)
White blood cells,9× 109/L	0.93 (0.256)	0.80 (0.256)
Neutrophils, × 10 /L	0.62 (0.153)	0.55 (0.164)
Lymphocytes, × 109/L	0.23 (0.140)	0.18 (0.137)
Monocytes, × 10 9/L	0.06 (0.038)	0.05 (0.016)
Eosinophils, × 10 /L	0.02 (0.013)	0.02 (0.010)
Clinical chemistry
AST, U/L	48 (10.8)	43 (8.3)
ALP, U/L	77 (8.1)	73 (6.0)
Urea, mmol/L	7.37 (0.619)	6.83 (0.483)
Cholesterol, mmol/L	1.94 (0.143)	1.81 (0.151)
Triglycerides, mmol/L	0.63 (0.271)	0.42 (0.220)
Glucose	15.09 (1.147)	11.93 (1.829)**
Na+, mmol/L	151 (1.3)	151 (2.9)**
K+, mmol/L	3.7 (0.30)	4.0 (0.29)*
Ca2+, mmol/L	2.39 (0.046)	2.34 (0.055)*
Albumin, g/L	31 (0.6)	31 (1.1)
Total protein, g/L	46 (1.2)	46 (1.3)

Animals were followed up for 13 weeks. Values are means (SD)

^*p<0.05

^**p<0.01 vs. vehicle group, t-test on log-transformed data (hematology) or t-test or Wilcoxon test (clinical chemistry), as appropriate.