3.

Univariate and multivariate analyses of PFS and multivariate analyses of OS in RH group

Characteristics	PFS								OS
	Univariate analysis				Multivariate analysis				Multivariate analysis
	HR	95% CI	P		HR	95% CI	P		HR	95%	P
PFS, progression-free survival; OS, overall survival; RH, radical hysterectomy; HPV, human papillomavirus; FIGO, International Federation of Gynecology and Obstetrics; LNM, lymph node metastasis; SCC-Ag, squamous cell carcinoma antigen; HR, hazard ratio; 95% CI, 95% confidence interval. *, SCC-Ag level was modeled as continuous variables, and the risk of disease progression was increased by 3.4% in univariate analysis with each 1 ng/mL of SCC-Ag increment.
HPV viral load
>Median	1				1				1
≤Median	4.414	2.039−9.557	0.0001		4.198	1.933−9.116	0.0003		3.853	1.766−8.404	0.0007
FIGO stage
IB1	1				1				1
IB2	1.885	0.921−3.855	0.0827		1.401	0.668−2.941	0.3720		1.387	0.646−2.976	0.4011
IIA	4.489	2.061−9.777	0.0002		3.526	1.574−7.899	0.0020		3.622	1.600−8.201	0.0027
LNM
Negative	1				1				1
Positive	4.705	2.527−8.726	<0.001		3.586	1.872−6.870	0.0001		4.284	2.205−8.322	<0.0001
Post-surgery adjuvant treatment
No	1
Yes	2.602	1.364−4.962	0.0037
SCC-Ag*	1.034	1.004−1.065	0.0278
Cervical stromal invasion
<1/3	1
1/3−2/3	4.962	1.871−13.159	0.0013
>2/3	4.764	1.731−13.108	0.0025
Tumor size (cm)
≤4	1
>4	1.874	1.014−3.463	0.0449