4.

Univariate and multivariate analyses of PFS and multivariate analyses of OS in CCRT group

Characteristics	PFS								OS
	Univariate analysis				Multivariate analysis				Multivariate analysis
	HR	95% CI	P		HR	95% CI	P		HR	95%	P
PFS, progression-free survival; OS, overall survival; CCRT, concurrent chemoradiotherapy; HPV, human papillomavirus; LNSCT, lymph node status determined by computed tomography; SCC-Ag, squamous cell carcinoma antigen; FIGO, International Federation of Gynecology and Obstetrics; Single LN, single lymph node diameter; Multi LNs, multiple lymph nodes diameter; HR, hazard ratio; 95% CI, 95% confidence interval. *, SCC-Ag level was modeled as continuous variables, and the risk of disease progression was increased by 1.3% in univariate analysis and 1.0% in multivariate analysis with each 1 ng/mL of SCC-Ag increment.
HPV viral load
>Median	1				1				1
≤Median	2.927	1.539−5.567	0.001		2.356	1.212−4.580	0.0115		2.228	1.154−4.300	0.0170
LNSCT
No LN	1				1				1
LN diameter ≤1 cm	1.938	0.751−5.000	0.1713		1.848	0.715−4.772	0.2040		2.152	0.819−5.657	0.1200
Single LN >1 cm	3.088	1.241−7.683	0.0153		2.289	0.904−5.799	0.0810		2.847	1.114−7.279	0.0289
Multi LNs >1 cm	7.594	3.590−16.065	<0.0001		5.835	2.685−12.680	<0.0001		8.261	3.783−17.845	<0.0001
SCC-Ag*	1.013	1.005−1.020	0.0007		1.010	1.002−1.019	0.0167
FIGO stage
IIB/IIIA	1
IIIB/IVA	1.242	0.661−2.335	0.5013