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. 2019 May 13;9:7292. doi: 10.1038/s41598-019-43739-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Myeloid and lymphoid cell phenotypes in peripheral blood of primary chimeric mice. Flow cytometry of peripheral blood from primary chimeric mice, showing total myeloid cells and neutrophils (a) and the major lymphoid cell phenotypes (b) as percentages of total donor leucocytes at 6 and 16 weeks post-transplantation. The proportions of myeloid cells and neutrophils were similar in DPP9^S729A-origin mice and WT-origin mice. Myeloid cells and neutrophils were decreased at 16 weeks compared with 6 weeks for both groups of mice. (a) The proportion of B cells at 6 weeks was perhaps less (p = 0.065) in DPP9^S729A-origin mice compared to WT-origin mice at 6 weeks, and was less compared to DPP9^S729A -origin mice at 16 weeks. (b) The proportion of T cells increased between 6 and 16 weeks in both DPP9^S729A-origin mice and WT-origin mice. (b) Mean, SD and individual data. n = 9 (6 weeks), n = 7 a 16 weeks. Significance; *p < 0.05, **p < 0.01, ***p < 0.001.