Fig. 1. Histology and immunohistochemistry of human dysplasia and oral cancer biopsies for LOX and LOXL2.

Biopsy samples were selected by the pathology service at Boston University Henry M. Goldman School of Dental Medicine and tissue sections were prepared and stained. Slides made from one selected subject from 3 to 5 subjects sampled in each category of dysplasia, differentiated oral cancer, and poorly differentiated oral cancer, respectively, are shown. Stained slides were imaged using an automated slide imager, and images were processed using Case Viewer software version 2.2 (Budapest, Hungary). Data indicate that LOXL2 was highly expressed in a variety of cancer cells and associated mesenchymal cells in human oral cancer, while LOX expression was more restricted