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. 2019 May 13;8(5):34. doi: 10.1038/s41389-019-0144-0

Fig. 4. LOXL2 promotes proliferation and EMT of primary tongue and cervical lymph node metastases.

Fig. 4

PXS-S1C attenuates expression of (a) PCNA and (b) LOXL2 in LY2 orthotopic tongue tumors in immunocompetent mice after 6 weeks of treatment, scale bar = 100 µm. Data are mean ± SD. ANOVA, p < 0.05, Tukey’s multiple comparisons test, *p < 0.05 indicate difference among the groups (n = 12 per group). PSX-S1C treatment of LY2 tongue orthotopic tumors in mice alters tongue and cervical lymph node (c) tumor cell morphology, (d) E-cadherin expression and (e) vimentin expression. The images were taken at ×10 and ×20 magnifications. Scale bar = 100 µm. Images are from mice at the 6-week time point