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. 2019 Apr 25;34(2):135–161. doi: 10.1007/s12250-019-00114-3

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — A pleiotropic role of ORF57 in KSHV posttranscriptional regulation. In the nucleus ORF57 prevents hyper-polyadenylation of ORF59 through interaction with RBM15, increases stability of nuclear non-coding PAN RNA via interaction with PABPC1 and stimulates splicing of K8 pre-mRNA by interacting with SRSF3. In the cytoplasm ORF57 promotes vIL-6 translation by preventing miRNA-containing RISC complex binding to vIL-6 mRNA and blocks the formation of stress granules by binding to PKR to prevent PKR activation and phosphorylation (gray circle with P) of translational activator eIF2α.