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. 2019 May 13;10:2128. doi: 10.1038/s41467-019-10110-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Promoter vs gene body mutations and their effect on MIC (y axis in mg per L) for four drugs (n = 1452). Wilcoxon rank sum test comparing each pair was significant at p < 0.01. For reference critical resistance testing concentration is 0.2 mg per L for INH, 5 mg per L for ETA, 100 mg per L for PZA, 5 mg per mL for EMB and indicated by the horizontal dotted line. Figure 2 can be regenerated using code in Supplementary Data 8 that will refer to data items provided in the Source Data file (compressed source data folder)