Table 2.

PVE for each drug attributable to subsets of genetic variations

Drug	All PVE	All SE	woDR PVE	woDR SE	woDRwoNC PVE	woDRwoNC SE	DR-related PVE	NC-related PVE
INH	0.809	0.020	0.732	0.032	0.723	0.029	0.08	0.01
RIF	0.838	0.017	0.701	0.034	0.692	0.033	0.14	0.01
RFB	0.833	0.023	0.722	0.041	0.693	0.042	0.11	0.03
EMB	0.748	0.027	0.674	0.036	0.665	0.035	0.07	0.01
PZA	0.659	0.038	0.634	0.044	0.602	0.043	0.03	0.03
KAN	0.833	0.022	0.671	0.040	0.658	0.041	0.16	0.01
AMI	0.879	0.019	0.639	0.057	0.640	0.055	0.24	<0.01
CAP	0.743	0.030	0.690	0.038	0.666	0.038	0.05	0.02
ETA	0.701	0.034	0.689	0.038	0.675	0.038	0.01	0.01
STR	0.710	0.033	0.604	0.047	0.601	0.045	0.11	<0.01
MXF	0.643	0.058	0.494	0.083	0.456	0.081	0.15	0.04

PVE all measurable genetic variation given along with PVE related to variation excluding known drug resistance regions and non-canonical regions associated in this study (n = 1452 isolates). Drug abbreviations detailed in Supplementary Table 2. PVE: proportion of variance explained. DR: drug resistance regions as detailed in the methods. NC: Non-canonical regions specified in Table 1. wo: without. SE: standard error