Table 2.
Drug | All PVE | All SE | woDR PVE | woDR SE | woDRwoNC PVE | woDRwoNC SE | DR-related PVE | NC-related PVE |
---|---|---|---|---|---|---|---|---|
INH | 0.809 | 0.020 | 0.732 | 0.032 | 0.723 | 0.029 | 0.08 | 0.01 |
RIF | 0.838 | 0.017 | 0.701 | 0.034 | 0.692 | 0.033 | 0.14 | 0.01 |
RFB | 0.833 | 0.023 | 0.722 | 0.041 | 0.693 | 0.042 | 0.11 | 0.03 |
EMB | 0.748 | 0.027 | 0.674 | 0.036 | 0.665 | 0.035 | 0.07 | 0.01 |
PZA | 0.659 | 0.038 | 0.634 | 0.044 | 0.602 | 0.043 | 0.03 | 0.03 |
KAN | 0.833 | 0.022 | 0.671 | 0.040 | 0.658 | 0.041 | 0.16 | 0.01 |
AMI | 0.879 | 0.019 | 0.639 | 0.057 | 0.640 | 0.055 | 0.24 | <0.01 |
CAP | 0.743 | 0.030 | 0.690 | 0.038 | 0.666 | 0.038 | 0.05 | 0.02 |
ETA | 0.701 | 0.034 | 0.689 | 0.038 | 0.675 | 0.038 | 0.01 | 0.01 |
STR | 0.710 | 0.033 | 0.604 | 0.047 | 0.601 | 0.045 | 0.11 | <0.01 |
MXF | 0.643 | 0.058 | 0.494 | 0.083 | 0.456 | 0.081 | 0.15 | 0.04 |
PVE all measurable genetic variation given along with PVE related to variation excluding known drug resistance regions and non-canonical regions associated in this study (n = 1452 isolates). Drug abbreviations detailed in Supplementary Table 2. PVE: proportion of variance explained. DR: drug resistance regions as detailed in the methods. NC: Non-canonical regions specified in Table 1. wo: without. SE: standard error