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. 2019 May 13;9:7276. doi: 10.1038/s41598-019-43532-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of 20 days pre-treatment with QTC-4-MeOBnE (0.1 and 1 mg/kg i.g.) on amyloid cascade expression of mice submitted to ICV infusion of STZ (3 mg/kg) or saline. BACE-1 expression in (a) PFC and (b) HC; γ- secretase expression in (c) PFC and (d) HC; Protein Precursor Amyloid (APP) expression in (e) PFC and (f) HC. Results are expressed as mean ± SEM. (n = 5–6). ^#p < 0.05 and ^###p < 0.001 when compared with the control group. *p < 0.05, **p < 0.01 and ***p < 0.001 when compared with the STZ group (two-way ANOVA followed by Newman-Keuls test).