Table 2.
Sensitivity analysis.
| Outcome (total included patients) | HR (95% CI) | P value | Heterogeneity | |
|---|---|---|---|---|
| Analysis performed via a fixed effects model | MACE (N = 3083) | 1.12 (1.02, 1.23) | P = 0.02 | I² = 3%, P = 0.38 |
| Stroke (N = 3864) | 1.15 (1.02, 1.29) | P = 0.02 | I² = 0%, P = 0.67 | |
| Analysis after excluding APPROACH trial performed via a random effects model | MACCE (N = 2544) | 1.65 (1.37, 1.99) | P < 0.001 | I² = 0%, P = 0.75 |
| Analysis after excluding FREEDOM trial performed via a random effects model | All-cause mortality (N = 2416) | 1.44 (1.22, 1.70) | P < 0.001 | I² = 0%, P = 0.91 |
| Analysis after excluding Luo trial performed via a random effects model | MI (N = 4090) | 1.24 (1.12, 1.36) | P < 0.001 | I² = 0%, P = 0.51 |
| Analysis after excluding APPROCH and FREEDOM trials performed via a random effects model | Repeat revascularization (N = 678) | 3.27 (1.71, 6.24) | P = 0.003 | I² = 28%, P = 0.24 |
Abbreviations: HR, hazard ratio; CI, confidence interval; MACE, major adverse cardiovascular events; MACCE, major adverse cardiac and cerebrovascular events.