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. 2019 May 7;10:1001. doi: 10.3389/fmicb.2019.01001

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Copyright © 2019 Wang, Li, Yao, Zhang, Hu, Carr, Duchêne, Zhang, Zhang, Zhou, Tong, Ding, Wang and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic diversity of the CVA4 polyprotein genes (n = 31). (A) Average pairwise genetic diversity of all CVA4 polyprotein genes was calculated using a sliding window of 300 nts with a step size of 50 nts. (B) Positional entropy values and the Sn values at partitions 1, 2, and 3 of each codon were estimated, respectively. ^∗∗∗p-value <0.001 in the Wilcoxon rank-sum test. (C) The Sn values of nucleotides at positions three of the codons were estimated in VP4, VP2, VP3, VP1, 2A, 2B, 2C, 3A, 3B, 3C, and 3D genes, respectively. ^∗∗∗p-value <0.001 in the Wilcoxon rank-sum test between 2B, 2C, 3A, 3C, 3D genes and VP4, VP2, VP3, VP1 genes, respectively.