Table 1.
The dysregulated AD genes.
| Gene | partners | DEG | p(DEGs) | AD | p(AD) | Aging | p(aging) |
|---|---|---|---|---|---|---|---|
| MAP1B | 364 | Yes | 9.2e-77 | Yes | 3.3e-05 | Yes | 5e-3 |
| PSAP | 337 | No | 0.03 | Yes | 0.6 | No | 0.01 |
| PGAM1 | 300 | Yes | 1.4e-24 | Yes | 0.04 | No | 2e-3 |
| ARID1B | 275 | No | 4.8e-4 | Yes | 0.36 | No | 6.5e-11 |
| SLC1A2 | 271 | No | 1.9e-40 | Yes | 6.1e-3 | No | 0.18 |
| TGFBR2 | 243 | Yes | 1.1e-72 | Yes | 6.4e-06 | No | 1.9e-14 |
| SREK1IP1 | 209 | No | 0.55 | Yes | 0.05 | No | 0.02 |
| SYNJ1 | 200 | Yes | 6.3e-13 | Yes | 0.15 | No | 0.41 |
| DOCK3 | 195 | Yes | 4.1e-11 | Yes | 0.01 | No | 0.22 |
| STAT3 | 182 | Yes | 3.41e-49 | Yes | 1e-3 | No | 1.9e-11 |
| SUCLA2 | 164 | Yes | 8.4e-13 | Yes | 0.49 | Yes | ee-3 |
| SERPINI1 | 153 | Yes | 5.9e-32 | Yes | 0.01 | Yes | 6.3e-4 |
| AMPH | 141 | No | 8.7e-22 | Yes | 0.4 | No | 0.19 |
| APP | 136 | Yes | 1.2e-11 | Yes | 0.23 | No | 0.38 |
| CLU | 130 | Yes | 0.24 | Yes | 0.66 | No | 0.02 |
| LRP1 | 126 | Yes | 2.9e-16 | Yes | 0.09 | No | 2.9e-05 |
| GABRG2 | 126 | No | 6.9e-11 | Yes | 0.63 | No | 0.18 |
| VAT1L | 121 | No | 7.9e-13 | Yes | 0.34 | No | 0.02 |
| PHF1 | 119 | No | 0.4 | Yes | 0.59 | No | 2e-2 |
| TAGLN3 | 113 | Yes | 6.2e-32 | Yes | 2.4e-07 | No | 5e-06 |
| FRMD6 | 109 | No | 1.5e-21 | Yes | 0.04 | No | 3.4e-4 |
| PDSS1 | 106 | No | 0.68 | Yes | 0.67 | Yes | 2.9e-4 |
| PPIA | 106 | Yes | 4.2e-45 | Yes | 0.01 | Yes | 7.34e-09 |
| INPP5D | 96 | Yes | 1.6e-27 | Yes | 2.3e-3 | No | 3.6e-06 |
| PRKCE | 94 | Yes | 4.3e-4 | Yes | 0.05 | Yes | 0.35 |
| APLP2 | 94 | No | 7.4e-07 | Yes | 0.05 | No | 0.16 |
| YWHAB | 94 | Yes | 1.4e-17 | Yes | 0.34 | Yes | 3.6e-3 |
| GABRG3 | 87 | Yes | 4.3e-11 | Yes | 0.96 | No | 0.74 |
| PPARA | 83 | Yes | 5.8e-31 | Yes | 2.9e-3 | No | 9.2e-05 |
| RAN | 83 | Yes | 0.03 | Yes | 0.36 | Yes | 9.4e-3 |
| VDAC1 | 83 | Yes | 3.9e-10 | Yes | 0.28 | Yes | 0.02 |
| AFF1 | 82 | Yes | 2.7e-24 | Yes | 0.13 | No | 5.9e-06 |
| PFDN2 | 81 | Yes | 4.5e-16 | Yes | 0.13 | Yes | 1.5e-09 |
| EBP | 80 | No | 3.6e-23 | Yes | 6.7e-3 | No | 6.5e-08 |
| LEMD2 | 78 | No | 0.01 | Yes | 0.82 | No | 4.7e-3 |
| PRKACB | 76 | No | 1.6e-3 | Yes | 0.53 | Yes | 0.02 |
| EID1 | 70 | Yes | 0.33 | Yes | 0.21 | No | 1.3e-3 |
| GSTO1 | 66 | Yes | 3.5e-26 | Yes | 0.01 | Yes | 1.1e-08 |
| CNTNAP2 | 66 | Yes | 1.5e-08 | Yes | 0.16 | No | 0.55 |
| GABRA3 | 65 | Yes | 6.8e-08 | Yes | 0.59 | No | 0.32 |
| ARHGAP20 | 64 | Yes | 1.3e-3 | Yes | 0.21 | Yes | 0.15 |
| PAK1 | 62 | Yes | 4.2e-09 | Yes | 0.61 | No | 8.6e-3 |
| THOP1 | 62 | No | 0.34 | Yes | 0.03 | Yes | 0.36 |
| AKT1S1 | 61 | Yes | 0.35 | Yes | 0.75 | No | 0.19 |
| PRNP | 60 | Yes | 4.1e-05 | Yes | 0.25 | No | 0.02 |
| RTN3 | 60 | Yes | 7.3e-14 | Yes | 0.14 | Yes | 4.3e-3 |
| STX2 | 60 | No | 0.94 | Yes | 0.73 | No | 0.22 |
| GAS7 | 59 | Yes | 0.01 | Yes | 1 | No | 0.02 |
| CCDC134 | 58 | No | 0.91 | Yes | 0.71 | No | 0.7 |
| GRM8 | 58 | Yes | 4.2e-12 | Yes | 0.34 | No | 0.06 |
| GAPDH | 55 | No | 0.04 | Yes | 0.28 | No | 0.06 |
| CHL1 | 53 | Yes | 4.1e-4 | Yes | 0.43 | Yes | 0.05 |
| CHRM4 | 52 | No | 1.5e-09 | Yes | 0.56 | No | 0.07 |
| GABRB2 | 50 | No | 5.3e-09 | Yes | 0.06 | No | 0.47 |
| NEDD4 | 50 | Yes | 0.43 | Yes | 1 | No | 0.07 |
| VSNL1 | 48 | Yes | 5.8e-05 | Yes | 0.48 | No | 0.12 |
| PSENEN | 47 | No | 3.9e-05 | Yes | 0.01 | No | 3.0e-3 |
| BECN1 | 46 | Yes | 0.97 | Yes | 0.47 | Yes | 0.28 |
| CHMP5 | 45 | Yes | 0.19 | Yes | 0.48 | Yes | 5.9e-4 |
| UBQLN1 | 44 | No | 0.91 | Yes | 0.57 | Yes | 0.01 |
| HECW1 | 44 | No | 0.04 | Yes | 0.21 | No | 0.94 |
| CSMD1 | 44 | Yes | 3.2e-09 | Yes | 0.8 | No | 0.15 |
| CHRM2 | 44 | Yes | 1.4e-3 | Yes | 0.48 | No | 0.08 |
| UCHL1 | 43 | Yes | 2.8e-11 | Yes | 9.7e-3 | No | 0.01 |
| PHYHD1 | 43 | Yes | 2.9e-3 | Yes | 0.85 | Yes | 0.07 |
| SCN1A | 41 | No | 0.11 | Yes | 0.8 | Yes | 0.37 |
| APBA1 | 41 | No | 0.06 | Yes | 0.25 | No | 0.12 |
| UQCR10 | 41 | Yes | 1.02e-05 | Yes | 0.03 | No | 7.9e-3 |