Table 4.

Overall response and clinical benefit rate according to estrogen receptor status.

References	N°	Type	Tumor used for ER analysis	Type of immunohistochemical analysis	Response rate [% (95% CI)]		Clinical benefit [% (95% CI)]
					ER+	ER–	ER+	ER–
Singh et al. (59); Whitney et al. (53)	46	TMX daily and MPA in alternating weeks	Before start of hormonal therapy	Staining intensity index with range 0–500 Cutoff 75	47 (25–70)	26 (9–42)	Not reported
Covens et al. (54)	53	Fulvestrant	Recurrence/metastasis	% of positive nuclei Cutoff 10%	16 (3–29)	0	45 (28–63)	18 (2–34)
Emons et al. (55)	27	Fulvestrant	Primary tumor	NR	11 (0–23)	0	Not reported
Lindemann et al. (57)	51	Examestane	Primary tumor or recurrence	Staining intensity index Cutoff: high intensity 10% of nuclei	10 (1–19)	0	35 (20–50)	0
Fleming et al. (56)	20	Temsirolimus and alternating MA or TMX	Primary tumor	Any level of staining	13 (0–31)	0	Not reported
Slomovitz et al. (58)	30	Everolimus and letrozole	Primary tumor or recurrence	Staining intensity index range 0–8 Cutoff: 3	Not reported		59 (39–80)	13 (0–35)

MPA, medroxyprogesterone-acetate; TMX, tamoxifen; MA, megestrol acetate.