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. 2019 May 13;9:7299. doi: 10.1038/s41598-019-43759-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MMP-9 is downregulated in stromal tissues of HCC patients. (a) Representative images of tissue staining of stromal tissues from normal and HCC human patients, scale bar = 20 µm. Each image is a single slice as observed through immunofluorescence imaging. Inset represents magnification of area inside white square. (b) Quantification of MMP-9 and α-SMA (alpha smooth muscle actin) staining. Data was obtained from 20 HCC patients and 10 healthy patients. Bars represent mean ± s.e.m. ***Represents t test, p < 0.001.