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. 2019 May 13;9:7260. doi: 10.1038/s41598-019-43677-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electrophysiological effects of IQM-PC330 and IQM-PC332 on K_V4.3 and K_V4.3/DREAM channels. (a,b) Bar charts comparing the inhibition of K_V4.3/DREAM currents measured at the maximum peak current and at the charge produced by IQM-PC330 and IQM-PC332. Insets show original current recordings. (c,d) Graphics showing the changes in the time constant of inactivation (τ_Inact) at different concentrations of IQM-PC330 and IQM-PC332. IQM-PC330 accelerates the τ_Inact making the monoexponential process observed under control conditions in a biexponential one with a fast and a slow τ_Inact (τ_Inact,f and τ_Inact,s, respectively). In both graphs, the solid line represents the mean control value of the τ_Inact. Insets show original normalized current records: control (black line) and with IQM-PC330 (blue line) or IQM-PC332 (red line). Note that IQM-PC332 (100 nM) accelerates the inactivation and at 3 μM slows down this process). (e,f) Effects of IQM-PC330 and IQM-PC332 (100 nM and 3 μM) on the activation kinetics. Note that IQM-PC332 (100 nM) accelerates the activation and at 3 μM slows down this process. (g,h) Effects of IQM-PC330 and IQM-PC332 on the recovery process. Dashed lines represent the recovery process of K_V4.3 current without DREAM. Note that both compounds slow the recovery process, reverting DREAM effects.