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. 2019 May 13;9:7260. doi: 10.1038/s41598-019-43677-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electrophysiological effects of IQM-PC330 and IQM-PC332 on K_V4.3/DREAM wt and K_V4.3/DREAM mutant channels. Top panels depict original records obtained with or without IQM-PC330 (a) or IQM-PC332 (b) in K_V4.3/DREAM wt and in K_V4.3/DREAM Y118A or K_V4.3/DREAM Y130A channels. Block produced by IQM-PC330 (1 and 3 μM) and IQM-PC332 (1 and 3 μM) of K_V4.3/DREAM Y118A and K_V4.3/DREAM Y130A channels measured at the peak and at the charge. Data are shown as mean ± SEM. *p < 0.05 vs block produced in K_V4.3/DREAM wt channels; **p < 0.01 vs block produced in K_V4.3/DREAM wt channels; ***p < 0.001 vs block produced in K_V4.3/DREAM wt channels.