Table 5.
Genetic association testing in the BMT cohort.
| Additive | Dominant | Recessive | ||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Allele | N | RR | P | RR | P | RR | P |
| RECIPIENTS | ||||||||
| rs782026 | T | 293 | 1.685 | 0.009 | 2.350 | 0.016 | 1.535 | 0.360 |
| rs16888361 | A | 300 | 1.416 | 0.140 | 1.590 | 0.150 | 1.462 | 0.460 |
| rs7846217 | C | 303 | 0.921 | 0.790 | 0.845 | 0.650 | 1.176 | 0.820 |
| rs10109853 | T | 293 | 1.109 | 0.620 | 1.342 | 0.430 | 0.982 | 0.960 |
| rs4503083 | A | 304 | 1.004 | 0.990 | 0.979 | 0.950 | 1.095 | 0.890 |
| DONORS | ||||||||
| rs782026 | T | 325 | 0.777 | 0.210 | 0.986 | 0.960 | 0.152 | 0.066 |
| rs16888361 | A | 32 | 0.932 | 0.770 | 0.923 | 0.780 | 0.900 | 0.860 |
| rs7846217 | C | 320 | 0.984 | 0.960 | 0.957 | 0.900 | 1.250 | 0.840 |
| rs10109853 | T | 314 | 1.217 | 0.400 | 0.789 | 0.430 | 2.214 | 0.012 |
| rs4503083 | A | 322 | 0.996 | 0.990 | 0.730 | 0.320 | 2.841 | 0.015 |
P-values and relative risk (RR) were calculated using competing risk logistic regression models, adjusting for HLA matching and underlying disease, considering transplant related mortality and relapse as competing risks. Statistically significant results are marked in bold. Nominally-significant results are highlighted in Italics.