Table 3.
Mean plasma complement and ACLA protein levels in aPL-positive subjects with (T) and without thrombosis (NT).
| n | Mean ± SD | 95% CI | p (NT vs. T) | |
|---|---|---|---|---|
| C3 protein (mg/dL) | 0.013 | |||
| NT | 284 | 120.2 ± 35.1 | 116.1–124.3 | |
| T | 236 | 128.1 ± 36.6 | 123.4–132.8 | |
| C4 protein (mg/dL) | 1.3 × 10−8 | |||
| NT | 282 | 17.7 ± 9.0 | 16.6–18.7 | |
| T | 235 | 22.7 ± 10.6 | 21.3–24.0 | |
| C4A protein (mg/dL) | 8.2 × 10−6 | |||
| NT | 273 | 9.6 ± 5.6 | 8.9–10.3 | |
| T | 233 | 12.1 ± 6.7 | 11.2–12.9 | |
| C4B protein (mg/dL) | 6.7 × 10−6 | |||
| NT | 283 | 8.3 ± 5.0 | 7.8–8.9 | |
| T | 234 | 10.5 ± 6.0 | 9.8–11.3 | |
| CFH protein (mg/dL) | 0.057 | |||
| NT | 249 | 52.3 ± 15.0 | 50.5–54.2 | |
| T | 207 | 49.9 ± 12.1 | 48.2–51.5 | |
| MBL protein | 0.0007 | |||
| NT | 242 | 0.167 ± 0.173 | 0.145–0.189 | |
| T | 214 | 0.117 ± 0.129 | 0.100–0.135 | |
| ACLA IgM protein (MPL) | 0.0022 | |||
| NT | 254 | 29.9 ± 37.5 | 25.3–34.6 | |
| T | 202 | 19.5 ± 33.2 | 14.9–24.1 | |
| ACLA IgG protein (GPL) | 0.0043 | |||
| NT | 254 | 29.6 ± 46.7 | 23.9–35.4 | |
| T | 206 | 45.1 ± 68.4 | 35.7–54.5 | |
| Odds ratio (95% CI) | p | |||
| LAC-Positivity (freq.) | 2.63 (1.76–3.94) | 1.3 × 10−6 | ||
| NT | 260 | 0.531 | ||
| T | 199 | 0.749 | ||
| Sex (F/M ratio) | 0.33 (0.20–0.54) | 7.2 × 10−6 | ||
| NT | 288 (262/26) | 10.0 | ||
| T | 237 (182/55) | 3.23 |
CI, confidence interval. Odds ratios were calculated for T vs. NT. p-values of statistical significance are in bold fonts.