Table 4.
Mean plasma protein concentrations of complement and ACLA in aPL-positive subjects with (S) and without (NS) SLE.
| n | Mean ± SD | 95% CI | p (NS vs. S) | |
|---|---|---|---|---|
| C3 protein (mg/dL) | 8.0 × 10−5 | |||
| NS | 230 | 130.8 ± 35.4 | 126.2–135.4 | |
| S | 290 | 118.3 ± 35.6 | 114.2–122.4 | |
| C4 protein (mg/dL) | 0.0006 | |||
| NS | 230 | 21.6 ± 9.6 | 20.4–22.9 | |
| S | 287 | 18.6 ± 10.3 | 17.4–19.8 | |
| C4A protein (mg/dL) | 0.0038 | |||
| NS | 228 | 11.6 ± 5.8 | 10.9–12.4 | |
| S | 278 | 10.0 ± 6.5 | 9.2–10.8 | |
| C4B protein (mg/dL) | 0.005 | |||
| NS | 230 | 10.1 ± 5.4 | 9.4–10.8 | |
| S | 287 | 8.7 ± 5.7 | 8.1–9.4 | |
| CFH protein (mg/dL) | 0.02 | |||
| NS | 203 | 52.9 ± 14.4 | 50.9–54.9 | |
| S | 253 | 49.9 ± 13.1 | 48.3–51.5 | |
| MBL protein | 0.29 | |||
| NS | 204 | 0.135 ± 0.140 | 0.116–0.154 | |
| S | 252 | 0.151 ± 0.168 | 0.130–0.172 | |
| ACLA IgM protein (MPL) | 0.22 | |||
| NS | 183 | 22.8 ± 29.6 | 18.5–27.1 | |
| S | 273 | 27.0 ± 39.7 | 22.3–31.8 | |
| ACLA IgG protein (GPL) | 0.0002 | |||
| NS | 187 | 48.8± 70.1 | 38.7–59.0 | |
| S | 273 | 28.2 ± 46.1 | 22.7–33.7 | |
| Odds ratio (95% CI) | p | |||
| LAC-positivity (freq) | 0.79 (0.54–1.16) | 0.22 | ||
| NS | 190 | 0.658 | ||
| S | 269 | 0.602 | ||
| Sex (F/M ratio) | 2.06 (1.27–3.33) | 0.0031 | ||
| NS | 232 (184/48) | 3.81 | ||
| S | 293 (260/33) | 7.62 | ||
LAC, lupus anticoagulant. Odds ratios were calculated for S vs. NS. p-values of statistical significance are in bold fonts.