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. 2019 May 7;10:885. doi: 10.3389/fimmu.2019.00885

Table 5.

Mean plasma protein levels of complement and ACLA in aPL-positive subjects segregated by thrombosis and SLE status.

n Concentrations 95% CI P To: TS To: So To: NTS TS: So TS: NTS So: NTS
C3 protein (RMSE: 35.4) mg/dL 0.011 2.6 × 10−5 0.18 0.19 0.26 0.011
1. To 126 133.6 ± 37.8 127.0–140.3
2. TS 110 121.8 ± 34.4 115.3–128.3
3. So 180 116.1 ± 36.2 110.8–121.5
4. NTS 104 127.3 ± 32.2 121.0–133.6
C4 protein (RMSE: 9.72) mg/dL 0.073 2.2 × 10−9 0.0004 0.0001 0.083 0.056
1. To 126 23.7 ± 9.7 22.0–25.4
2. TS 109 21.4 ± 11.5 19.2–23.6
3. So 178 16.8 ± 9.0 15.5–18.1
4. NTS 104 19.1 ± 8.8 17.4–20.8
C4A protein (RMSE: 6.12) mg/dL 0.247 1.9 × 10−6 0.017 0.0009 0.23 0.049
1. To 126 12.5 ± 5.9 11.5–13.5
2. TS 107 11.6 ± 7.6 10.1–13.0
3. So 171 9.0 ± 5.6 8.2–9.9
4. NTS 102 10.5 ± 5.6 9.5–11.6
C4B protein (RMSE: 5.46) mg/dL 0.045 1.3 × 10−6 0.0008 0.012 0.19 0.31
1. To 126 11.2 ± 5.3 10.3–12.2
2. TS 108 9.8 ± 6.7 8.5–11.0
3. So 179 8.1 ± 4.9 7.4–8.8
4. NTS 104 8.8 ± 5.2 7.8–9.8
CFH protein (RMSE:13.7) mg/dL 0.059 0.78 0.121 0.079 0.001 0.053
1. To 111 51.5 ± 13.6 49.0–54.1
2. TS 96 47.9 ± 9.7 46.0–49.9
3. So 157 51.1 ± 14.6 48.8–53.4
4. NTS 92 54.5 ± 15.4 51.3–57.7
MBL protein (RMSE: 0.154) mg/dL 0.95 0.0041 0.078 0.0046 0.076 0.42
1. To 114 0.118 ± 0.140 0.092–0.144
2. TS 100 0.117 ± 0.115 0.094–0.139
3. So 152 0.173 ± 0.192 0.143–0.204
4. NTS 90 0.157 ± 0.137 0.128–0.185
ACLA-IgM protein (RMSE: 35.7) g/L 0.28 0.0039 0.013 0.092 0.092 0.95
1. To 101 16.8 ± 24.7 11.9–21.7
2. TS 101 22.3 ± 39.9 14.4–30.1
3. So 172 29.8 ± 39.5 23.9–35.8
4. NTS 82 30.1 ± 33.4 22.8–37.5
ACLA-IgG protein (RMSE: 56.9) g/L 0.0063 1.2 × 10−5 0.058 0.17 0.488 0.041
1. To 103 56.0 ± 87.7 38.9–73.1
2. TS 103 34.3 ± 38.5 26.7–41.8
3. So 170 24.5 ± 49.9 17.0–32.0
4. NTS 84 40.1 ± 37.8 31.9–48.3
LAC-positivity (Frequency) 0.65 0.0002 0.015 3.8 × 10−5 0.0048 0.39
1. To 102 0.735
2. TS 97 0.763
3. So 172 0.512
4. NTS 88 0.568
Sex (F/M ratio) 0.0005 1.6 × 10−6 3.4 × 10−7 0.43 0.088 0.26
1. To 126 2.07
2. TS 111 6.40
3. So 182 8.58
4. NTS 106 14.1

p-values of statistical significance are in bold fonts.