. 2019 May 7;10:885. doi: 10.3389/fimmu.2019.00885

Table 7.

Plasma complement and ACLA levels and risk factors for recurrent pregnancy loss (RPL) in female aPL-positive subjects.

*a. Continuous data*		n	Mean ± SD	95% CI	P
C3 Protein, mg/dL	N-RPL	336	123.6 ± 34.0	120.0–127.3	0.23
	RPL	105	131.8 ± 41.8	123.1–140.4
C4 protein, mg/dL	N-RPL	334	19.2 ± 9.9	18.1–20.2	0.009
	RPL	103	22.1 ± 9.6	19.9–23.7
C4A protein	N-RPL	324	10.3 ± 5.9	9.6–10.91	0.039
	RPL	103	11.7 ± 5.5	10.5–12.8
C4B protein	N-RPL	333	9.1± 5.5	8.5–9.7	0.051
	RPL	104	10.3 ± 5.8	9.2–11.4
CFH protein, mg/dL	N-RPL	296	52.1 ± 14.2	50.5–53.7	0.019
	RPL	87	48.8 ± 10.4	46.6–51.0
MBL protein, mg/dL	N-RPL	269	0.166 ± 0.164	0.147–0.185	0.051
	RPL	84	0.128 ± 0.130	0.100–0.156
ACLA-IgM g/L	N-RPL	300	26.8 ± 37.2	22.6–31.0	0.56
	RPL	90	33.6 ± 108.5	10.9–56.4
ACLA IgG, g/L	N-RPL	301	30.0 ± 51.1	24.2–35.8	0.01
	RPL	91	44.2 ± 43.7	35.1–53.3
b. Categorical data		Case/total	f	P	Remarks
C4T, GCN = 2	N-RPL	7/261	0.0269	0.15
	RPL	5/79	0.0633
C4A, GCN = 0	N-RPL	0/263	0	0.0001	Risk
	RPL	5/81	0.0617
C4B, GCN = 0	N-RPL	11/261	0.0421	0.017	Protective
	RPL	0/75	0
LAC-Positivity	N-RPL	168/294	0.584	0.057
	RPL	64/94	0.671
Thromboses	N-RPL	114/338	0.337	5.1 × 10⁻⁸	Risk
	RPL	67/105	0.638
SLE	N-RPL	136/338	0.414	0.32
	RPL	48/105	0.467
c. Subgroup freq.	T_o	S_o	TS	NTS	p
N-RPL, n (%)	61 (18.1)	149 (44.1)	53 (15.7)	75 (22.2)	3.8 × 10⁻¹⁰
RPL, n (%)	24 (22.9)	14 (13.3)	43 (40.1)	24 (22.9)
S_o, p	7.2 × 10⁻⁵	-
TS, p	0.021	1.6 × 10⁻¹¹	-
NTS, p	0.54	0.0006	0.0024	-

f, frequency; N-RPL, no recurrent pregnancy loss; RPL, with recurrent pregnancy loss. p-values of statistical significance are in bold fonts.