B. Mean gene copy numbers (±SD) for total C4, C4A and C4B among aPL-positive subjects.
	N	total C4 GCN	C4A GCN	C4B GCN
a. Thrombosis (T) and non-thrombosis (NT)
NT	263	3.741 ± 0.378	1.989 ± 0.696	1.753 ± 0.633
T	209	3.670 ± 0.613	1.866 ± 0.636	1.804 ± 0.541
	P	0.24	0.049	0.36
b. SLE (S) and non-SLE (NS)
NS	206	3.782 ± 0.637	2.014 ± 0.702	1.767 ± 0.636
S	266	3.654 ± 0.656	1.872 ± 0.643	1.782 ± 0.561
	p	0.035	0.022	0.79
c. Thrombosis and SLE status
1. To	109	3.780 ± 0.567	1.917 ± 0.579	1.862 ± 0.552
2. TS	100	3.550 ± 0.642	1.810 ± 0.692	1.740 ± 0.524
3. So	166	3.717 ± 0.659	1.910 ± 0.611	1.807 ± 0.582
4. NTS	97	3.784 ± 0.710	2.124 ± 0.807	1.660 ± 0.705
To vs. TS	P	0.011	0.25	0.14
To vs. So	P	0.43	0.93	0.45
To vs. NTS	P	0.97	0.027	0.015
TS vs. So	P	0.042	0.24	0.37
TS vs. NTS	P	0.012	0.001	0.34
So vs. NTS	P	0.42	0.012	0.052

T_o, thrombosis without SLE; TS, thrombotic SLE; S_o, SLE without thrombosis; NTS, non-thrombosis and non-SLE; f, frequency. GCN, gene copy number. The reference values for mean GCNs of total C4, C4A, and C4B are 3.82 ± 0.75, 2.09 ± 0.79, and 1.74 ± 0.63, respectively, for healthy subjects; and 3.56 ± 0.77, 1.81± 0.89, and 1.76 ± 0.58, respectively, for SLE subjects (38). p values < 0.05 were in bold fonts.