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. 2019 May 7;10:997. doi: 10.3389/fimmu.2019.00997

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Copyright © 2019 Chatterjee, Roy, Sarkar, Zhao, Ratra, Singh, Chawla, De, Gomes, Sen and Basak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brief TNF stimulation induces delayed, RelB-dependent gene expression in Nfkb2^−/− MEFs. (A) WT and knockout MEFs were subjected to TNFc treatment for 6 h, and the expressions of the indicated genes belonging to different gene-groups were measured by qRT-PCR. Bargraphs demonstrate the abundances of the corresponding mRNAs in stimulated cells relative to those measured in untreated cells. Data represent three biological replicates. (B–E) WT and Nfkb2^−/− MEFs were subjected to TNFc or briefly stimulated with TNF for 0.5 h (TNFp), and subsequently cells were harvested at the indicated time-points before being subjected to qRT-PCR analyses. Bargraphs demonstrate TNF-induced expressions of the indicated genes, representing various gene-groups, in relation to untreated cells. Data represent four independent experiments. Quantified data presented in this figure are means ± SEM.