Figure 4.

Interconnection of the pathways studied, the genes in which we have measured expression and connection to mitochondrial respiration. The colors represent the groups that have elevations in the expression of specific genes. Most notable are the two pathways by which mTOR can influence mitochondrial function. S6K1 pathway inhibits many of the pathways involved in mitochondrial maintainance and response to stress while the 4E-BP/eIF4E pathway more directly can increase mitochondrial function.