Figure 6.

Rapamycin modulates mitochondrial function differently depending on the underlying baseline repiratory rate in lymphobastoid cell lines (LCLs) derived from children with autistic disorder (AD). (A–D) Group differences in the effect of rapamycin. The AD-N LCLs demonstrate more typical mitochondrial function and have less influence from rapamycin while the AD-A LCLs, which demonstrate elevated mitochondrial function, are more influenced by rapamycin. (E–H) The linear relationship between the underlying baseline respiratory rate and the change in respirataory rate for both groups of LCLs. The higher the baseline respiratory rate, the greater the effect of rapamycin.