Table 4.
Distribution of known and novel complex CNVs (Deletion+Duplication) in AZF regions and their effects on SF.
| Complex CNVs types | Controls | Patients | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Normozoospermia (n = 402) | Spermatogenic failure (n = 423) | Azoospermia (n = 197) | Oligozoospermia (n = 226) | |||||||||||
| n | OR | P | n | OR(95%CI) | P | n | OR(95%CI) | P | n | OR(95%CI) | P | |||
| Deletion + Duplication | AZFc | b2/b3 del + DAZ1/2 dup | 2 | 1.00 | – | 11 | 5.34 | 3.00 ×10−2 | 3 | 3.09 | 2.18 × 10−1 | 8 | 7.34 | 1.22 ×10−2 |
| (1.18–24.24) | (0.51–18.66) | (1.55–34.87) | ||||||||||||
| b2/b3 del + gr/gr dup* | 6 | 1.00 | – | 8 | 0.81 | 7.10 × 10−1 | 2 | 0.68 | 6.35 × 10−1 | 6 | 1.80 | 3.14 × 10−1 | ||
| (0.27–2.44) | (0.14–3.39) | (0.57–5.65) | ||||||||||||
| b2/b3 del + gr/gr trip* | 2 | 1.00 | – | 5 | 2.39 | 2.99 × 10−1 | 0 | – | – | 5 | 4.53 | 7.26 × 10−1 | ||
| (0.46–12.04) | (0.87–23.52) | |||||||||||||
| two gr/gr dels + b2/b4 dup | 2 | 1.00 | – | 3 | 1.43 | 6.97 × 10−1 | 3 | 3.09 | 2.18 × 10−1 | 0 | – | – | ||
| (0.24–8.59) | (0.51–18.66) | |||||||||||||
| gr/gr del + b2/b3 trip* | 2 | 1.00 | – | 1 | 0.47 | 5.43 × 10−1 | 0 | – | – | 1 | 0.89 | 9.24 × 10−1 | ||
| (0.04–5.25) | (0.08–9.86) | |||||||||||||
*
indicated that the CNV was not reported previously; del, deletion; dels, deletions; dup, duplication; trip, triplication; P-values < 0.05 were considered significant.
The bold values mean P-value < 0.05.