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. 2019 May 7;7:300. doi: 10.3389/fchem.2019.00300

Table 2.

Pyrrolidine ring expansion by reaction with different nucleophilesa.

Entry Nucleophile Yield (%)
Inline graphic Inline graphic
36a−e 36a−e
1 graphic file with name fchem-07-00300-i0003.jpg 46 32
2 graphic file with name fchem-07-00300-i0004.jpg 56 37
3 graphic file with name fchem-07-00300-i0005.jpg 11 89
4 graphic file with name fchem-07-00300-i0006.jpg 23 56
5 graphic file with name fchem-07-00300-i0007.jpg 35 23
a

Reaction conditions: 33: 35a-e in 1: 1 molar ratio, in ACN heated in a autoclave to 180°C for 5–24 h.