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Medulloblastoma tumor with APC mutation. Magnetic resonance image of the tumor with cerebellar midline location (a); ALK immunopositive reaction present in > 80% of tumor cells (b); result of NGS analysis displaying the presence of the c.3366_3369del APC variant in heterozygous state in DNA extracted from patient’s leukocytes (c) and in homozygous state in tumor sample (d). Preparation was scanned at original magnification × 40 and digital magnification presented on image is × 20
