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. 2019 May 7;10:1022. doi: 10.3389/fimmu.2019.01022

Figure 1.

Figure 1

The effect of administering the fatty acid-binding protein (FABP) with and without the anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody (mAb) on the percentage of regulatory T cells (Tregs) in mice infected with Schistosoma japonicum. (A) Representative flow cytometry data showing splenocyte Treg percentages in mice in the uninfected, infected control, anti-CTLA-4 mAb, FABP, and combination groups at 5 weeks after S. japonicum infection. Upper panels: P2 gate shows the frequency of CD4+CD25+ T cells in isolated splenocytes. Lower panels: Q2–2 gate indicates the proportion of Foxp3+ lymphocytes in the P2 gate (upper panels). (B) Frequencies of Tregs in total splenocytes in the five mouse treatment groups at 5 weeks post-infection (i.e., 3 weeks post anti-CTLA-4 mAb administration). Data are presented as the mean ± S.D for experiments performed in triplicate. *P < 0.05.