Table 3.
Clinical parameters during follow up.
| TD subtype | Indeterminant subtype | PIGD subtype | P-value | |
|---|---|---|---|---|
| H &Y STAGE | ||||
| Baseline (325) | 1.5 ± 0.5a | 1.9 ± 0.4b | 1.6 ± 1.5a | 0.001 |
| 1 year (325) | 1.7 ± 0.5 | 1.9 ± 0.3 | 1.7 ± 0.6 | 0.09 |
| 2 years (325) | 1.7 ± 0.5a | 2.0 ± 0.5b | 1.8 ± 0.6a | <0.01 |
| 4 years (325) | 1.8 ± 0.5 | 2.0 ± 0.5 | 2.0 ± 0.8 | 0.06 |
| MDS- UPDRS II | ||||
| Baseline | 5.9 ± 3.6a (221) | 9.4 ± 4.5b (29) | 8.0 ± 4.3b (75) | <0.001 |
| 1 year | 7.5 ± 4.6a (203) | 11.0 ± 4.8b (26) | 9.0 ± 4.5 (70) | <0.001 |
| 2 years | 8.1 ± 4.7a (206) | 11.9 ± 5.3b (28) | 9.4 ± 5.6 (71) | <0.001 |
| 4 years | 10.3 ± 6.0a (204) | 13.9± 6.2b (26) | 11.5 ± 7.8 (73) | <0.05 |
| MDS- UPDRS III | ||||
| Baseline | 20.1 ± 8.6a (221) | 25.2 ± 8.9b (29) | 20.1 ± 8.0a (75) | <0.001 |
| 1 year | 22.8 ± 10.1 (203) | 27.8 ± 9.3 (26) | 23.0 ± 10.8 (70) | 0.07 |
| 2 years | 24.3 ± 11.2a (206) | 30.0 ± 11.8b (28) | 26.6 ± 12.0 (71) | <0.05 |
| 4 years | 29.8 ± 11.2 (182) | 32.5 ± 12.4 (22) | 30.9 ± 14.2 (69) | 0.57 |
| SCOPA-AUT | ||||
| Baseline | 8.4 ± 5.8 (221) | 10.6 ± 5.0 (29) | 9.4 ± 5.9 (75) | 0.09 |
| 1 year | 9.3 ± 7.0a (221) | 12.6 ± 7.6b (29) | 11.0 ± 6.7 (75) | <0.05 |
| 2 years | 12.1 ± 7.0 (206) | 14.1 ± 6.1 (28) | 13.1 ± 7.9 (71) | 0.30 |
| 4 years | 12.3 ± 7.3 (203) | 16.0 ± 7.4 (26) | 13.4 ± 8.5 (72) | 0.05 |
| MOCA | ||||
| Baseline | 27.2 ± 2.2 (221) | 26.3 ± 2.7 (29) | 27.2 ± 2.4 (75) | 0.14 |
| 1 year | 26.5 ± 2.7 (220) | 26.2 ± 2.8 (29) | 26.5 ± 2.6 (75) | 0.84 |
| 2 years | 26.7 ± 2.7 (203) | 25.6 ± 3.7 (28) | 26.3 ± 2.6 (71) | 0.13 |
| 4 years | 26.8 ± 3.1 (208) | 26.0 ± 4.2 (27) | 26.5 ± 3.7 (73) | 0.54 |
For a particular variable, values with different superscripts indicate statistically significant difference. The values in parentheses represent the number of patients.