Table 1. Baseline characteristics in reference to on-treatment level of LDL cholesterol and Hs-CRP.
| Characteristic | LDL cholesterol |
P value | CRP |
P value | ||
|---|---|---|---|---|---|---|
| < 120 mg/dL | > 120 mg/dL | < 1 mg/L | > 1 mg/L | |||
| (N = 591) | (N = 486) | (N = 732) | (N = 345) | |||
| Age, years | 66.8 ± 8.5 | 65.7 ± 8.4 | 0.040 | 66.0 ± 8.6 | 67.0 ± 8.1 | 0.084 |
| Male, N (%) | 416 (70.4) | 323 (66.5) | 0.188 | 474 (64.8) | 265 (76.8) | < .0001 |
| BMI, kg/m2 | 23.60 ± 3.10 | 23.82 ± 2.92 | 0.241 | 23.48 ± 3.01 | 24.15 ± 3.00 | 0.001 |
| Interval between index Stroke and enrollment, Months | 9.52 ± 9.83 | 9.60 ± 10.50 | 0.905 | 9.81 ± 10.21 | 9.01 ± 9.98 | 0.223 |
| Total cholesterol, mg/dl | 202.0 ± 23.1 | 219.4 ± 24.4 | < .0001 | 210.0 ± 24.9 | 209.5 ± 26.0 | 0.743 |
| HDL cholesterol, mg/dl | 55.2 ± 17.7 | 50.3 ± 11.8 | < .0001 | 54.9 ± 16.2 | 48.9 ± 12.9 | < .0001 |
| Triglyceride, mg/dl | 141.5 ± 83.4 | 145.3 ± 68.9 | 0.417 | 134.7 ± 67.7 | 161.3 ± 91.6 | < .0001 |
| Hypertension, N (%) | 458 (77.5) | 367 (75.5) | 0.489 | 543 (74.2) | 282 (81.7) | 0.008 |
| Systolic blood pressure, mmHg | 137.2 ± 17.8 | 135.8 ± 17.5 | 0.178 | 136.6 ± 17.5 | 136.6 ± 18.1 | 0.994 |
| Diastolic blood pressure, mmHg | 79.3 ± 11.5 | 79.2 ± 11.1 | 0.827 | 79.3 ± 11.3 | 79.0 ± 11.6 | 0.663 |
| Diabetes mellitus, N (%) | 151 (25.5) | 101 (20.8) | 0.077 | 173 (23.6) | 79 (22.9) | 0.850 |
| Fasting blood glucose, mg/dl | 121.8 ± 47.3 | 113.1 ± 35.7 | 0.001 | 116.9 ± 43.5 | 120.0 ± 40.9 | 0.257 |
| Coronary artery disease, N (%) | 29 (4.9) | 25 (5.1) | 0.968 | 37 (5.1) | 17 (4.9) | 1.000 |
| Chronic kidney disease, N (%) | 150 (25.4) | 116 (23.9) | 0.616 | 165 (22.5) | 101 (29.3) | 0.021 |
| Creatinine, mg/dl | 0.806 ± 0.202 | 0.800 ± 0.219 | 0.631 | 0.784 ± 0.198 | 0.844 ± 0.228 | < .0001 |
| Smoker, N (%) | 326 (55.2) | 251 (51.6) | 0.270 | 355 (48.5) | 222 (64.3) | < .0001 |
| Use of antiplatelet agents, N (%) | 545 (92.2) | 440 (90.5) | 0.383 | 674 (92.1) | 311 (90.1) | 0.347 |
| Use of statin, N (%) | 388 (65.7) | 148 (30.5) | < .0001 | 375 (51.2) | 161 (46.7) | 0.183 |
| Ischemic stroke subtype | ||||||
| Atherothrombotic infarction, N (%) | 154 (26.1) | 121 (24.9) | 0.507 | 181 (24.7) | 94 (27.2) | 0.215 |
| Lacunar infarction, N (%) | 369 (62.4) | 318 (65.4) | 479 (65.4) | 208 (60.3) | ||
| Undetermined etiology, N (%) | 68 (11.5) | 47 (9.7) | 72 (9.8) | 43 (12.5) | ||
| LDL cholesterol, mg/dL | ||||||
| Baseline | 118.9 ± 22.5 | 143.2 ± 20.4 | < .0001 | 129.2 ± 24.6 | 131.4 ± 24.9 | 0.164 |
| On-treatment | 101.7 ± 12.9 | 136.5 ± 13.2 | < .0001 | 116.5 ± 21.7 | 119.2 ± 21.4 | 0.058 |
| CRP, Median, mg/L (IQR) | ||||||
| Baseline | 0.636 (0.344–1.470) | 0.755 (0.369–1.690) | 0.041 | 0.488 (0.256–0.769) | 1.940 (1.240–4.110) | < .0001 |
| On-treatment | 0.599 (0.327–1.130) | 0.711 (0.387–1.395) | 0.008 | 0.448 (0.261–0.659) | 1.820 (1.310–2.860) | < .0001 |
The categorical data are compared by chi-square test and the numerical data are compared by non-paired t-test, and Wilcoxon two-sample test for Hs-CRP. TIA: transient ischemic attack, BMI: body mass index, HDL: high density lipoprotein, LDL: low density lipoprotein, Hs-CRP: high-sensitivity C reactive protein, IQR: interquartile range